Metabolic syndrome

Incidence for metabolic syndrome in rheumatic disease

  • There have been consistent reports of high prevalence of metabolic syndrome in patients with rheumatic disease.
  • The prevalence of metabolic syndrome in rheumatic disease patients has been reported to be ∼42%, depending on the diagnostic criteria used, which is obviously higher than those reported in general population (28%).

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Mechanism for metabolic syndrome in rheumatic disease

  • Rheumatic disease is a chronic inflammatory disease.
  • A chronic inflammatory state triggers release of numerous inflammatory mediators into blood, leading to development of insulin resistance and metabolic syndrome.

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Risk factors for metabolic syndrome in rheumatic diseases

  • In addition to general risk factors of metabolic syndrome, such as, demographic, disease-related, and life style-related risk factors, a chronic inflammatory state and use of steroids are also risk factors of metabolic syndrome in rheumatic disease.

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